Blar i forfatter "Høieggen, Aud"

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    • Associations of urinary orosomucoid, N-acetyl-β-D-glucosaminidase, and albumin with blood pressure and hypertension during 7 years of follow-up. The Tromsø Study 

      Brobak, Karl Marius; Andreassen, Runa Marie; Melsom, Toralf; Høieggen, Aud; Norvik, Jon Viljar; Solbu, Marit Dahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-03)
      Purpose: Subclinical chronic kidney disease is known to exacerbate hypertension and progression of kidney damage. In order to initiate timely interventions, early biomarkers for this vicious circle are needed. Our aim was to describe the cross-sectional associations of urinary orosomucoid and urinary N-acetyl-b-D-glucosaminidase (NAG) with blood pressure and the longitudinal associations of urinary ...

    • Detection of Nonadherence to Antihypertensive Treatment by Measurements of Serum Drug Concentrations 

      Bergland, Ola Undrum; Halvorsen, Lene Vernås; Søraas, Camilla Lund; Hjørnholm, Ulla; Kjær, Vibeke Norheim; Rognstad, Stine; Brobak, Karl Marius; Aune, Arleen; Olsen, Eirik; Fauchald, Ylva; Heimark, Sondre; Thorstensen, Christian W; Liestøl, Knut; Solbu, Marit Dahl; Gerdts, Eva; Mo, Rune; Rostrup, Morten; Kjeldsen, Sverre; Høieggen, Aud; Opdal, Mimi Stokke; Fadl Elmula, Fadl Elmula M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-19)
      Nonadherence to drugs is a challenge in hypertension treatment. We aimed to assess the prevalence of nonadherence by serum drug concentrations compared with 2 indirect methods and relate to the prescribed drug regimens in a nationwide multicenter study. Five hundred fifty patients with hypertension using ≥2 antihypertensive agents participated. We measured concentrations of 23 antihypertensive drugs ...

    • Development of UHPLC-MS/MS methods to quantify 25 antihypertensive drugs in serum in a cohort of patients treated for hypertension 

      Thorstensen, Christian W.; Clasen, Per-Erik; Rognstad, Stine; Haldsrud, Renate; Føreid, Siri; Helstrøm, Trine; Bergland, Ola Undrum; Halvorsen, Lene Vernås; Aune, Arleen; Olsen, Erik; Brobak, Karl Marius; Høieggen, Aud; Gustavsen, Ingebjørg G.; Larstorp, Anne Cecilie Kjeldsen; Søraas, Camilla Lund; Opdal, Mimi Stokke (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-23)
      We developed three ultra-high pressure liquid chromatography coupled to mass spectrometry detection (UHPLCMS/MS) methods to quantify 25 antihypertensive drugs in serum samples. Patient-reported drug lists were collected, and drug concentrations were analysed in samples from 547 patients, half with uncontrolled hypertension, and all treated with ≥ 2 antihypertensive drugs. For sample preparation, ...

    • Gender differences in association between uric acid and all-cause mortality in patients with chronic heart failure 

      Stubnova, Viera; Os, Ingrid; Høieggen, Aud; Solbu, Marit Dahl; Grundtvig, Morten; Westheim, Arne; Atar, Dan; Waldum-Grevbo, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-05)
      <p><i>Background - </i>Elevated serum uric acid (SUA) is associated with poor prognosis in patients with cardiovascular disease, yet it is still not decided whether the role of SUA is causal or only reflects an underlying disease. The purpose of the study was to investigate if SUA was an independent predictor of 5-year all-cause mortality in a propensity score matched cohort of chronic heart failure ...